Dr. Kristian M. Hargadon


Dr. Kristian HargadonElliott Assistant Professor of Biology
Gilmer Hall, 108
(434) 223-6261
khargadon@hsc.edu

Education

B.S., Hampden-Sydney College, 2001; Ph.D., University of Virginia, 2007; Postdoctoral Fellow, University of Virginia, 2007-2009

Teaching Interests

Microbiology
Immunology
Virology
Biology of Cancer
Principles of Biology
Genetics
Cell Biology

Committee Assignments & Service to the College

Admissions & Financial Aid Committee (2014-2015)

Bortz Award Selection Committee (2013, 2014)

Sophomore Vocational Reflection Project Discussion Leader (2013, 2014)

Member of Learning Communities Action Team for Student Engagement Initiative (2013-2014)

Organized and hosted the inaugural Longwood University/Hampden-Sydney College Sigma Xi Research Day Symposium (2013)

Academic Affairs Committee (2011-2013)

Professional Development Committee (2011-2014, Chair 2013-2014)  

Health Sciences Advisory Committee (2011- prsent, Chair 2012-present)       

Presidential Inauguration Installation Ceremony Committee

Technical Services Librarian Search Committee

Freshmen Advising

Virginia Private College Week Volunteer (2010-present)

Open House Recruiting

Big Event Community Service Project (2011, 2013, 2014)

Most Recent Publications

Kristian M. Hargadon.  2014.  Murine and Human Model Systems for the Study of Dendritic Cell Immunobiology.  International Reviews of Immunology.  Published online ahead of print September 9, 2014.  

Kristian M. Hargadon and Timothy N. J. Bullock.  2014.  The Role of Tumor/Dendritic Cell Interactions in the Regulation of Anti-tumor Immunity: The Good, The Bad, and The Ugly.  Frontiers in Immunology.  5: 178.

Kristian M. Hargadon.  2013.  Tumor-altered Dendritic Cell Function:  Implications for Anti-tumor Immunity.  Frontiers in Immunology.  4: 192.  ***Article featured in the Global Medical Discovery Series.

Kristian M. Hargadon.  2013.  Melanoma Immunotherapy:  Overcoming Obstacles to Augment Anti-tumor Immune Responses.  Journal of Cosmetics, Dermatological Sciences and Applications.  3, 2A:  7-27.

Kristian M. Hargadon, Yonathan T. Ararso, Osric A. Forrest, and Chad M. Harte.  2012.  Melanoma-associated Suppression of the Dendritic Cell Lines DC2.4 and JAWSII.  American Journal of Immunology.  8:  179-190.

Kristian M. Hargadon, Osric A. Forrest, and Pranay R. Reddy.  2012.  Suppression of the Maturation and Activation of the Dendritic Cell Line DC2.4 by Melanoma-derived Factors.  Cellular Immunology.  272:  275-282. 

Kristian M. Hargadon, H. Zhou, R.A. Albrecht, H.A. Dodd, A. Garcia-Sastre, and T.J. Braciale.  2011.  Major Histocompatibility Complex Class II Expression and Hemagglutinin Subtype Influence the Infectivity of Type A Influenza Virus for Respiratory Dendritic Cells.  2011.  Journal of Virology.  85:  11955-11963.  

Ferguson, A.R., L.A Nichols, A.L. Zarling, E.D. Thompson, C.C. Brinkman, K.M. Hargadon, T.N. Bullock, and V.H. Engelhard. 2008. Strategies and challengesin eliciting immunity to melanoma. Immunological Reviews. 222: 28-42.

Hargadon, K.M., C. C. Brinkman, S. L. Sheasley-O'Neill, L. A. Nichols, T. N. J. Bullock and V. H. Engelhard. 2006. Incomplete Differentiation of Antigen-Specific CD8 T Cells in Tumor-Draining Lymph Nodes. Journal of Immunology. 177: 6081-6090.

Recent Presentations

Jay Brandt and Kristian M. Hargadon. 2014. Ex vivo Analysis of the Impact of Melanoma-altered Dendritic Cells on CD8+ T Cell Differentiation. Poster presentation at James Madison University at the 2014 Virginia Branch Meeting of the American Society for Microbiology.

Hampden-Sydney College Wilson Center for Leadership Current Events Series – Ebola.  September 3, 2014.

E. D. Carter, R. M. Goodman, and Kristian M. Hargadon. 2014. Survey of ranavirus in central Virginia reptiles. Poster presentation at 2014 Ecological Society of America Annual Meeting (Sacramento, CA).

Smoking, Alcohol, and Cancer.  2014.  Presented to Hampden-Sydney College students and staff to raise awareness during fraternity pledge period.

Jonathan D. Bishop and Kristian M. Hargadon.  Suppression of Dendritic Cell Maturation, Activation, and T Cell Stimulatory Capacity by Melanoma-derived Factors.  Poster presentation at the 2013 VA Branch Meeting of the American Society for Microbiology at the University of Virginia.

Yonathan T. Ararso and Kristian M. Hargadon.  Melanoma-derived Factors TGFb1 and VEGF-A Suppress Anti-tumor Immunity by Interfering with Dendritic Cell Maturation and Activation.  Poster presentation at the 2013 Leadership Alliance National Symposium in Stamford, CT.

2013 - Invited speaker at tjSTAR Symposium to Advance Research at Thomas Jefferson High School in Alexandria , VA

Kristian M. Hargadon.  From Gym Rat to Tumor Immunologist: A Scholar-Athlete's Path to Cancer Research.  Keynote speaker at the 2013 Harker Research Symposium at The Harker School in San Jose, CA.

Kristian M. Hargadon, Osric A. Forrest, and Pranay R. Reddy.  Suppression of the Maturation and Activation of the Dendritic Cell Line DC2.4 by Melanoma-derived Factors.  Oral presentation at Norfolk State University at the 2012 Virginia Academy of Science Annual Meeting.

Yonathan T. Ararso and Kristian M. Hargadon.  The Role of Melanoma-derived Immunosuppressive Molecules in the Suppression of Dendritic Cell Maturation and Activation.  Poster presentation at Randolph-Macon College at the 2012 Virginia Collegiate Honors Council Spring Conference.

Yonathan T. Ararso and Kristian M. Hargadon.  Characterization of B16-F1 and D5.1G4 Melanoma Tumors and Profiling Melanoma-Induced Suppression of Dendritic Cell Function.  Poster presented at the Raleigh Convention Center in Raleigh, NC at the 2011 Sigma Xi Annual Meeting and International Research Conference.

Osric A. Forrest and Kristian M. Hargadon.  The Effect of B16-F1 and D5.1G4 Tumor-altered Dendritic Cells on Helper and Killer T Cell Activation.  Poster presentation at J. Sargeant Reynolds Community College at the 2011 Virginia Academy of Science Fall Undergraduate Research Conference.

2011 Graduation Speaker at Blessed Sacrament Huguenot High School Graduation

Kristian M. Hargadon, Osric A. Forrest, and Pranay R. Reddy.  Melanoma-Associated Suppression of Dendritic Cell Maturation/Activation Depends on Tumorigenicity.  Oral presentation at University of Richmond at the 2011 Virginia Academy of Science Annual Conference.

Pranay Reddy and Kristian M. Hargadon.  Characterization of the Murine Melanoma Cell Lines B16-F1 and D5.1G4: A Model System for Investigating Immune Regulation by Highly Tumorigenic Versus Poorly Tumorigenic Melanomas.  Poster presentation at Marymount University at the 2011 Virginia Collegiate Honors Council Spring Conference.

Kristian M. Hargadon and Osric Forrest.  Progressor Versus Regressor Melanomas Differentially Suppress Dendritic Cell Activation.  Oral presentation at Lynchburg College at the 2010 Virginia Branch of the American Society for Microbiology Meeting.

Chad M. Harte and Kristian M. Hargadon.  Characterizing Maturation of the Immature Dendritic Cell Line JAWSII.  Poster presentation at Virginia Wesleyan College at the 2010 Virginia Collegiate Honors Council Spring Conference.  RECEIVED BEST POSTER AWARD.

Kristian M. Hargadon and Thomas J. Braciale.  Susceptibility and Responsiveness of Respiratory Dendritic Cells to Influenza Virus Infection is Virus Strain-Dependent.  Oral presentation at Virginia Commonwealth University at the 2009 Virginia Branch of the American Society for Microbiology Meeting.

Kristian M. Hargadon.  Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome:  What is the "Deficiency"?  Presented as an Invited Speaker at the Hampden-Sydney College symposium: Global HIV and AIDS Pandemic: It's In Your Life.  November 5, 2009

Honors/Awards

2014 - Commonwealth Health Research Board Grant for project entitled "The Role of Melanoma-derived Factors in Suppressing the Maturation, Activation, and T Cell Stimulatory Capacity of Dendritic Cells" ($125,000)

2014 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2014 - Renewal of Virginia Academy of Science Jeffress Memorial Fellowship ($10,000); Total Grant Award = $45,000

2013 - Virginia Foundation for Independent Colleges Mednick Memorial Fellowship ($2,000)

2013 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2012 - Elliott Endowed Professorship

2012 - Renewal of Virginia Academy of Science Jeffress Memorial Fellowship ($10,000)

2012 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2012 - J. Shelton Horsley Research Award (highest honor bestowed by Virginia Academy of Science for original research) for manuscript published in Cellular Immunology entitled "Suppression of the maturation and activation of the dendritic cell line DC2.4 by melanoma-derived factors."

Sigma Xi Fresh Faces of the 125th Anniversary Award (1 of 125 members out of 60,000+ worldwide in the international honorary scientific research society recognized as an emerging "Fresh Face" under the age of 35 in scientific research)

2011 - Virginia Academy of Science Jeffress Memorial Fellowship ($25,000)

2011 - Virginia Foundation for Independent Colleges Mednick Memorial Fellowship,($2,000)                        

2011 - Hampden-Sydney Student/Faculty Summer Research Award ($4,000)

2010 - Virginia Foundation for Independent Colleges (VFIC) Undergraduate Science Research Fellowship and Hampden-Sydney Student/Faculty Summer Research Award

2010 - Hampden-Sydney Student/Faculty Summer Research Award ($4,000)

Postdoctoral Fellow Immunology Training Grant and Biodefense Training Grant
Who's Who Among American Teachers & Educators
Dean's Fellowship - University of Virginia
Barry M. Goldwater Scholar
Valedictorian - Hampden-Sydney College - 2001
USA Today All-USA College Academic Team - Third Team
Patrick Henry Scholar - Hampden-Sydney College

Professional Affiliations

Virginia Academy of Sciences (Vice Chair (2011), Secretary (2012), and Chair (2013) of Biology with Microbiology and Molecular Biology Division)
American Association for the Advancement of Science
Sigma Xi Honorary Scientific Research Society (President of Longwood University/Hampden-Sydney College Chapter, 2013-present)
Omicron Delta Kappa Honorary Leadership Fraternity
Phi Beta Kappa Honorary Fraternity
Chi Beta Phi Honorary Science/Mathematics Fraternity
Eta Sigma Phi Honorary Classics Fraternity

Alpha Chi Sigma - Professional Member

Additional Activities

Guest Associate Editor for Research Topic covering Tumor Cell/Dendritic Cell Interactions and the Influence of Tumors on Dendritic Cell-mediated Anti-Tumor Immune Responses and Dendritic Cell-Based Tumor Immunotherapies in the journal Frontiers in Tumor Immunity

Reviewer for the journal Cellular Immunology 

Reviewer for the journal Frontiers in Immunology

Reviewer for the journal Melanoma Research

Reviewer for the journal Immunological Investigations

Reviewer for the journal Human Immunology

Reviewer for the journal Immunology

Reviewer for the journal OncoTargets and Therapy

Reviewer for the journal Annual Research & Review in Biology

Reviewer for the journal Current Medicinal Chemistry

Reviewer for the textbook Kuby, Immunology (7th Edition) 

Other Interests  

Juggling
Sports (Basketball, Football, Golf, Tennis)