May 18, 2011
Dr. Nolan A. Wages '04, Assistant Professor of Mathematics and Computer Science, has received a grant from the National Institutes of Health.
The grant, entitled 'Designs for Phase 1 Trials of Combinations of Agents,' is part of the National Cancer Institute at the National Institutes of Health and is collaborative work between Dr. Wages, Dr. Mark Conaway and Dr. Paula Fracasso at the University of Virginia, Dr. John O'Quigley at Inserm, Université Paris VI and Dr. Alexia Iasonos at Memorial Sloan-Kettering Cancer Center in Manhattan.
Phase 1 clinical trials aim at finding a safe and efficient drug administration in humans. This grant will focus on the design of Phase 1 trials that involve the investigation of two or more drugs, which could have a major impact on the way these trials are conducted. Dose-finding trials of combinations of agents are becoming increasingly common in cancer research. While there are many proposed methods for single agent trials, there are relatively few options for designing phase 1 trials of combinations. As in single agent trials, it is crucial to find a combination of doses that can be administered with an acceptable rate of toxic side effects in order that these new therapies can be tested for effectiveness. Without adequate statistical methods, potentially effective combinations may be discarded as too toxic. Typically, the doses of only one of the multiple agents are escalated. This grant addresses dose escalation of multiple agents simultaneously.