• Chair, Elliott Associate Professor of Biology

    Gilmer Hall, 109
    (434) 223-6261
    khargadon@hsc.edu


  

Education

Postdoctoral Fellow, University of Virginia, 2007-2009

Ph.D., University of Virginia, 2007 

B.S., Hampden-Sydney College, 2001

Teaching Interests

Microbiology
Immunology
Virology
Biology of Cancer
Principles of Biology
Genetics
Cell Biology

Committee Assignments & Service

Panelist for Hampden-Sydney College's "The Good Man & Good Citizen of Today" Panel Discussion.  2018 Reunion Weekend/Summer College.  June 2, 2018.

Panelist for Hampden-Sydney College Higher Educational Consultants Association Panel Discussion.  April 24, 2018.

Hampden-Sydney College Athletics Hall of Fame Selection Committee (2018-present)

Chapter Advisor - Alpha Epsilon Delta - The Health Preprofessional Honor Society (2017-present)

Promotion and Tenure Committe (2017-2020, Chair 2019-2020))

Faculty Affairs Committee (2017)

ODK Cares for Kids Program Volunteer (2016)

Tigers Serve Freshmen Orientation Community Service Project Leader (2016)

Math & Science Day Workshop Leader for Prince Edward County 8th Graders (2016)

Judge - Fuqua Middle School Science Fair (2016)

President - Hampden-Sydney College Phi Beta Kappa Chapter (2016-2018)

Clinical Coordinator - H-SC/Centra Pre-Health Rotational Shadowing Program (2015-present)

Allen-Madison Scholar Selection Committee (2015)

Panelist for Hampden-Sydney College Future Educators Club "Alumni in Education" Panel Discussion.  April 13, 2015.

Admissions & Financial Aid Committee (2014-2015)

Bortz Award Selection Committee (2013, 2014)

Barry M. Goldwater Scholar On-campus Interviewing Committee (2013 - present)

Volunteer for "MAN UP with Admissions" Recruitment and Engagement Program (2013-present)

Sophomore Vocational Reflection Project Discussion Leader (2013, 2014)

Member of Learning Communities Action Team for Student Engagement Initiative (2013-2014)

Organized and hosted the Longwood University/Hampden-Sydney College Sigma Xi Research Day Symposium (2013, 2015)

Fulbright Scholarship On-campus Interviewing Committee (2011-present)Academic Affairs Committee (2011-2013)

Professional Development Committee (2011-2014, Chair 2013-2014)  

Health Sciences Advisory Committee (2011- prsent, Chair 2012-present)       

Panelist for Hampden-Sydney College QEP Symposium "College Men:  Making the Grade?  A Symposium at Hampden-Sydney College About the Education of Men" (member of panel discussion on "Alums Teaching at Single-Sex Institutions").  February 23, 2012.

Presidential Inauguration Installation Ceremony Committee

Technical Services Librarian Search Committee

Freshmen Advising

Virginia Private College Week Volunteer (2010-present)

Open House Recruiting

Big Event Community Service Project (2011, 2013, 2014, 2017)

Publications

* Denotes undergraduate co-author

1. Kristian M. Hargadon, B. Győrffy, E.W. Strong*, B.D. Tarnai*, J.C. Thompson*, D.Z. Bushhouse*, C.E. Johnson *, and C.J. Williams*.  The FOXC2 Transcription Factor Promotes Melanoma Outgrowth and Regulates Expression of Genes Associated With Drug Resistance and Interferon Responsiveness.  Cancer Genomics & ProteomicsIn press – Article accepted for publication August 19, 2019.

2. Kristian M. Hargadon, Coleman E. Johnson*, and Corey J. Williams*.  Immune Checkpoint Blockade Therapy for Cancer:  An Overview of FDA-approved Immune Checkpoint Inhibitors.  International Immunopharmacology.  2018.  62:  29-39.  Also featured in International Immunopharmacology's Special Issue on "Cellular Therapeutics in the Context of Immunopharmacology."

3.  R.M. Goodman, Kristian M. Hargadon, and E.D. Carter*. Detection of Ranavirus in Eastern Fence Lizards and Eastern Box Turtles in Central Virginia. Northeastern Naturalist. 2018.  25:  391-398.

4.  Kristian M. Hargadon.  Strategies to Improve the Efficacy of Dendritic Cell-Based Immunotherapy for Melanoma.  Frontiers in Immunology.  2017. 8: 1594.

5.   Kristian M. Hargadon.  Dysregulation of TGFβ1 Activity in Cancer and Its Influence on the Quality of Anti-Tumor Immunity.  Journal of Clinical Medicine.  2016.  5: 76 (1-22).

6.   Kristian M. Hargadon.  A Model System for the Study of Gene Expression in the Undergraduate Laboratory.  Biochemistry and Molecular Biology Education.  2016.  44:  397-404.   

7.  Kristian M. Hargadon.  The Extent to which Melanoma Alters Tissue-resident Dendritic Cell Function Correlates with Tumorigenicity.  OncoImmunology.  2016.  5 (1): e1069462.   

8.  Kristian M. Hargadon, Jonathan Drake Bishop*, John Patrick Brandt*, Zachary Charles Hand*, Yonathan Tarekegne Ararso*, and Osric Anthony Forrest*.  Melanoma-derived Factors Alter the Maturation and Activation of Differentiated Tissue-resident Dendritic Cells.    Immunology and Cell Biology.  2016.  94:  24-38.  Also one of twelve articles selected by journal editors to be re-featured in Immunology and Cell Biology's 2019 Virtual Issue on "Cancer Immunotherapy." 

9.   Kristian M. Hargadon.  Murine and Human Model Systems for the Study of Dendritic Cell Immunobiology.  International Reviews of Immunology.  2016.  35:  85-115.     

10.   Kristian M. Hargadon.  Whole Genome Expression Microarray Analysis of Highly Versus    Poorly Tumorigenic Murine Melanoma Cell Lines Provides Insights into Factors that Regulate Tumor Growth, Metastasis, and Immunogenicity.  Frontiers in Immunology.  2015.  6: 452.   

11. Kristian M. Hargadon and Timothy N. J. Bullock.   The Role of Tumor/Dendritic Cell Interactions in the Regulation of Anti-tumor Immunity: The Good, The Bad, and The Ugly.  Frontiers in Immunology.  2014.  5: 178.   

12. Kristian M. Hargadon.  Tumor-altered Dendritic Cell Function:  Implications for Anti-tumor Immunity.  Frontiers in Immunology.  2013.  4: 192.  ***Article featured in the Global Medical Discovery Series.   

13. Kristian M. Hargadon.  Melanoma Immunotherapy:  Overcoming Obstacles to Augment  Anti-tumor Immune Responses.  Journal of Cosmetics, Dermatological Sciences and Applications.  2013.  3, 2A:  7-27.   

14.  Kristian M. Hargadon, Yonathan T. Ararso*, Osric A. Forrest*, and Chad M. Harte*.     Melanoma-associated Suppression of the Dendritic Cell Lines DC2.4 and JAWSII.  American Journal of Immunology.  2012.  8:  179-190.   

15. Kristian M. Hargadon, Osric A. Forrest*, and Pranay R. Reddy*.  Suppression of the Maturation and Activation of the Dendritic Cell Line DC2.4 by Melanoma-derived Factors.  Cellular Immunology.  2012.  272:  275-282.    

16. Kristian M. Hargadon, H. Zhou, R.A. Albrecht, H.A. Dodd*, A. Garcia-Sastre, and T.J.   Braciale.  2011.  Major Histocompatibility Complex Class II Expression and Hemagglutinin Subtype Influence the Infectivity of Type A Influenza Virus for Respiratory Dendritic Cells.  Journal of Virology.  2011.  85:  11955-11963.     

17. A.R. Ferguson, L.A Nichols, A.L. Zarling, E.D. Thompson*, C.C. Brinkman*, Kristian M.  Hargadon, T.N. Bullock, and V.H. Engelhard. Strategies and challengesin eliciting immunity to melanoma. Immunological Reviews. 2008. 222: 28-42.   

18. Kristian M. Hargadon, C. C. Brinkman*, S. L. Sheasley-O'Neill, L. A. Nichols, T. N. J. Bullock and V. H. Engelhard. Incomplete Differentiation of Antigen-Specific CD8 T Cells in Tumor-Draining Lymph Nodes. Journal of Immunology. 2006. 177: 6081-6090.

Book Chapters (* = undergraduate student co-author)

  1. Kristian M. Hargadon and Coleman E. Johnson*. A Melanoma Cell/Lymphatic Endothelial Cell Adhesion Assay.  Chapter in Melanoma – Methods and Protocols (Methods in Molecular Biology, Volume Forthcoming), K.M. Hargadon, Editor, Springer Nature/Humana Press.  Forthcoming in 2020. 

Edited Books and Journal Special Issues

  1. Kristian M. Hargadon, Editor. Melanoma – Methods and Protocols (Methods in Molecular Biology, Volume Forthcoming in 2020).  New York: Springer Nature/Humana Press.  Under contract.
  2. Kristian M. Hargadon and Timothy N. J. Bullock, Editors.  Frontiers in Immunology Research Topic "Tumor Cell/Dendritic Cell Interactions and the Influence of Tumors on Dendritic Cell-mediated Anti-Tumor Immune Responses and Dendritic Cell-Based Tumor Immunotherapies." 2014.

Recent Presentations (* denotes undergraduate co-author)

David Z. Bushhouse* and Kristian M. Hargadon.  2019.  Chemokine Receptor Expression Profiling of Lymph Node Invasive Versus Lymph Node Non-invasive Melanomas.  Poster presentation at the 2019 Annual Meeting of the American Association for Cancer Research (Atlanta, GA).

Corey J. Williams*, Coleman E. Johnson*, David Z. Bushhouse*, and Kristian M. Hargadon.  2019.  The FOXC2 Transcription Factor Promotes Growth of Melanoma Cells in both in vitro and in vivo Settings.  Poster presentation at the 2019 Annual Meeting of the American Association for Cancer Research (Atlanta, GA).  Honorable Mention Award to Corey Williams for presentation also given at the AACR's Undergraduate Student Caucus and Poster Competition, held in conjunction with the main meeting.

Coleman E. Johnson*, Corey J. Williams*, and Kristian M. Hargadon.  2019.  FOXC2-associated Regulation of Melanoma Cell Adhesion to the Extracellular Matrix and Lymphatic Endothelial Cells.  Poster presentation at the 2019 Annual Meeting of the American Association for Cancer Research (Atlanta, GA).

Moderator for “Rhetoric at Work” Panel Discussion as part of the Hampden-Sydney College Rhetoric Program’s 40th Anniversary Celebration

Kristian M. Hargadon.  2018.  The Influenza Pandemics:  How a Virus with 8 Genes Can Kill Millions.  Hampden-Sydney College 2018 Influenza Symposium to Commemorate the 100-year Anniversary of the 1918 Influenza Pandemic.

Kristian M. Hargadon.  2018.  A Model System for the Study of Gene Expression in the Undergraduate Laboratory.  Oral presentation at the 2018 Annual Meeting of the Virginia Academy of Science (Longwood University, Farmville, VA).

David Z. Bushhouse* and Kristian M. Hargadon.  2018.  CRISPR-Cas9-mediated Disruption of the Foxc2 Gene in a Murine Melanoma Cell Line as a Tool for Investigating FOXC2 Gene Targets that Promote Melanoma Progression.  Oral presentation at the 2018 Annual Meeting of the Virginia Academy of Science (Longwood University, Farmville, VA).  

Corey J. Williams* and Kristian M. Hargadon.  2018.  FOXC2 Regulates Expression of the Integrins ITGA5 and ITGA9 in Melanoma.  Oral presentation at the 2018 Annual Meeting of the Virginia Academy of Science (Longwood University, Farmville, VA).

Coleman E. Johnson* and Kristian M. Hargadon.  2018.  FOXC2 is a Key Regulator of Melanoma Cell Adhesion to the Extracellular Matrix and Lymphatic Endothelial Cells.  Oral presentation at the 2018 Annual Meeting of the Virginia Academy of Science (Longwood University, Farmville, VA).  

David Bushhouse and Kristian M. Hargadon.  2017.  Optimization of a Chromatin Immunoprecipitation Assay to Assess Target Genes of the FOXC2 Transcription Factor in Melanoma.  Poster presentation at the 2017 Annual Meeting of the American Society for Cell Biology (Philadelphia, PA).

Coleman Johnson, Corey Williams, and Kristian M. Hargadon.  2017.  The FOXC2 Transcription Factor is a Critical Regulator of Integrin Expression and Tumor Cell Adhesion in Melanoma.  Poster presentation at the 2017 Annual Sigma Xi Symposium and Student Research Conference (Raleigh, NC).

David Bushhouse and Kristian M. Hargadon.  2017.  Optimization of a Chromatin Immunoprecipitation Assay to Assess Target Genes of the FOXC2 Transcription Factor in Melanoma.  Poster presentation at the 2017 Annual Sigma Xi Symposium and Student Research Conference (Raleigh, NC).  

Kristian M. Hargadon. Tipping the Balance in the War on Cancer:  How Insights into the Basic Biology of Tumor Progression are Revolutionizing Cancer Therapy.  Keynote Address at Virginia Academy of Science Fall 2017 Undergraduate Research Meeting.  

David Bushhouse and Kristian M. Hargadon.  2017.  Identification of FOXC2 Target Genes in Melanoma Through Chromatin Immunoprecipitation.  Poster presentation at the 2017 Virginia Academy of Science Undergraduate Research Meeting.  RECEIVED BEST POSTER/GRANT AWARD - GENETICS SECTION.

Kristian M. Hargadon, Jefferson C. Thompson, Travis B. Goodloe III, James H. Lau, Corey J. Williams, Coleman E. Johnson, and David Z. Bushhouse.  2017.  Melanoma-associated FOXC2 is a Critical Regulator of Tumor Cell Adhesion, Invasion, and Lymph Node Metastasis.  Oral presentation at Commonwealth of Virginia Cancer Research Conference (University of Virginia).

James H. Lau and Kristian M. Hargadon.  2017.  Assessing the Role of Melanoma-associated FOXC2 in Tumor Cell Migration, Invasion, and Immune Suppression.  Poster presentation at the 2017 American Association for Cancer Research Undergraduate Student Caucus and Poster Competition at the AACR Annual Meeting (Washington, D.C.).

Brant D. Boucher and Kristian M. Hargadon.  2017. Evaluating a Tissue-Specific Gene Silencing Approach to Knock Down FOXC2 Gene Expression in Melanoma Cells.  Poster presentation at the 2017 American Association for Cancer Research Undergraduate Student Caucus and Poster Competition at the AACR Annual Meeting (Washington, D.C.). 

Brant Boucher, Michael J. Wolyniak, Kristian M. Hargadon, and Rupak Dua.  2017. Biomimetic Nano-Patterned Design on the Surface of the Implants to Prevent Bacterial Infection.  Poster presentation at the 2017 National Meeting of the American Society of Biochemistry and Molecular Biology (Chicago, IL). 

Brant D. Boucher and Kristian M. Hargadon.  2017. Evaluating a Tissue-Specific Gene Silencing Approach to Knock Down FOXC2 Gene Expression in Melanoma Cells.  Poster presentation at the Virginia Academy of Science Student Research Showcase at the Virginia House of Delegates.

James H. Lau and Kristian M. Hargadon.  2016.  Profiling Differential Gene and Protein Expression between the Murine Melanoma Cell Lines B16-F1 and B16-F1ΔFoxc2 via Flow Cytometry, qRT-PCR, and ELISA.  Poster presentation at Virginia Western Community College at the 2016 Virginia Branch Meeting of the American Society for Microbiology.

Brant D. Boucher and Kristian M. Hargadon.  2016. Evaluating a Tissue-Specific Gene Silencing Approach to Knock Down FOXC2 Gene Expression in Melanoma Cells.  Poster presentation at Virginia Western Community College at the 2016 Virginia Branch Meeting of the American Society for Microbiology.

Jefferson C. Thompson and Kristian M. Hargadon.  2016.  Generation of a Foxc2 Gene Knockout Murine Melanoma Cell Line via CRISPR-Cas9 Genome Editing Technology.  Poster presentation at 2016 Experimental Biology Meeting in San Diego, CA.

Travis B. Goodloe, III and Kristian M. Hargadon.  2016.  Validation of a Quantitative Polymerase Chain Reaction (qPCR)-based Method for Detecting Lymph Node Metastasis by Melanoma Cells.  Poster presentation at 2016 Experimental Biology Meeting in San Diego, CA.

Jefferson C. Thompson and Kristian M. Hargadon.  2015.  Generation of a Foxc2 Gene Knockout Murine Melanoma Cell Line via CRISPR-Cas9 Genome Editing Technology.  Poster presentation at J. Sergeant Reynolds Community College at the 2015 Virgina Branch Meeting of the American Society for Microbiology.

Travis B. Goodloe, III and Kristian M. Hargadon.  2015.  Validation of a Quantitative Polymerase Chain Reaction (qPCR)-based Method for Detecting Lymph Node Metastasis by Melanoma Cells.  Poster presentation at J. Sergeant Reynolds Community College at the 2015 Virgina Branch Meeting of the American Society for Microbiology.  Received 1st Place Award in Poster Competition (judged from among 59 poster presentations by both undergraduate and graduate students)

Hampden-Sydney College Future Educators Club "Alumni in Education" Panel Discussion

Stephen Woodall and Kristian M. Hargadon. 2015. Genetic Engineering of the Murine Melanoma D5.1G4 to Express a Model Antigen for Evaluation of Anti-tumor CD8+ T Cell Responses.  Poster presentation at the 2015 National Meeting of the American Society for Biochemistry and Molecular Biology (Boston, MA).  Received Thematic Best Poster Award for the theme Molecular Mechanisms of Infection and Immunity.

Jay Brandt and Kristian M. Hargadon. 2014. Ex vivo Analysis of the Impact of Melanoma-altered Dendritic Cells on CD8+ T Cell Differentiation. Poster presentation at James Madison University at the 2014 Virginia Branch Meeting of the American Society for Microbiology.Hampden-Sydney College Wilson Center for Leadership Current Events Series - Ebola.  September 3, 2014.

Smoking, Alcohol, and Cancer.  2014.  Presented to Hampden-Sydney College students and staff to raise awareness during fraternity pledge period.

E. D. Carter*, R. M. Goodman, and Kristian M. Hargadon. 2014. Survey of ranavirus in central Virginia reptiles. Poster presentation at the 2014 Ecological Society of America Annual Meeting (Sacramento, CA).

Jonathan D. Bishop and Kristian M. Hargadon.  Suppression of Dendritic Cell Maturation, Activation, and T Cell Stimulatory Capacity by Melanoma-derived Factors. Poster presentation at the 2013 VA Branch Meeting of the American Society for Microbiology at the University of Virginia.

Yonathan T. Ararso and Kristian M. Hargadon.  Melanoma-derived Factors TGFb1 and VEGF-A Suppress Anti-tumor Immunity by Interfering with Dendritic Cell Maturation and Activation.  Poster presentation at the 2013 Leadership Alliance National Symposium in Stamford, CT.

2013 - Invited speaker at tjSTAR Symposium to Advance Research at Thomas Jefferson High School in Alexandria , VA

Kristian M. Hargadon.  From Gym Rat to Tumor Immunologist: A Scholar-Athlete's Path to Cancer Research.  Keynote speaker at the 2013 Harker Research Symposium at The Harker School in San Jose, CA.

Kristian M. Hargadon, Osric A. Forrest, and Pranay R. Reddy.  Suppression of the Maturation and Activation of the Dendritic Cell Line DC2.4 by Melanoma-derived Factors.  Oral presentation at Norfolk State University at the 2012 Virginia Academy of Science Annual Meeting.

Yonathan T. Ararso and Kristian M. Hargadon.  The Role of Melanoma-derived Immunosuppressive Molecules in the Suppression of Dendritic Cell Maturation and Activation.  Poster presentation at Randolph-Macon College at the 2012 Virginia Collegiate Honors Council Spring Conference.

Yonathan T. Ararso and Kristian M. Hargadon.  Characterization of B16-F1 and D5.1G4 Melanoma Tumors and Profiling Melanoma-Induced Suppression of Dendritic Cell Function.  Poster presented at the Raleigh Convention Center in Raleigh, NC at the 2011 Sigma Xi Annual Meeting and International Research Conference.

Osric A. Forrest and Kristian M. Hargadon.  The Effect of B16-F1 and D5.1G4 Tumor-altered Dendritic Cells on Helper and Killer T Cell Activation.  Poster presentation at J. Sargeant Reynolds Community College at the 2011 Virginia Academy of Science Fall Undergraduate Research Conference.

2011 Graduation Speaker at Blessed Sacrament Huguenot High School Graduation

Kristian M. Hargadon, Osric A. Forrest, and Pranay R. Reddy.  Melanoma-Associated Suppression of Dendritic Cell Maturation/Activation Depends on Tumorigenicity.  Oral presentation at University of Richmond at the 2011 Virginia Academy of Science Annual Conference.

Pranay Reddy and Kristian M. Hargadon.  Characterization of the Murine Melanoma Cell Lines B16-F1 and D5.1G4: A Model System for Investigating Immune Regulation by Highly Tumorigenic Versus Poorly Tumorigenic Melanomas.  Poster presentation at Marymount University at the 2011 Virginia Collegiate Honors Council Spring Conference.

Kristian M. Hargadon and Osric Forrest.  Progressor Versus Regressor Melanomas Differentially Suppress Dendritic Cell Activation.  Oral presentation at Lynchburg College at the 2010 Virginia Branch of the American Society for Microbiology Meeting.

Chad M. Harte and Kristian M. Hargadon.  Characterizing Maturation of the Immature Dendritic Cell Line JAWSII.  Poster presentation at Virginia Wesleyan College at the 2010 Virginia Collegiate Honors Council Spring Conference.  RECEIVED BEST POSTER AWARD.

Kristian M. Hargadon and Thomas J. Braciale.  Susceptibility and Responsiveness of Respiratory Dendritic Cells to Influenza Virus Infection is Virus Strain-Dependent.  Oral presentation at Virginia Commonwealth University at the 2009 Virginia Branch of the American Society for Microbiology Meeting.

Kristian M. Hargadon.  Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome:  What is the "Deficiency"?  Presented as an Invited Speaker at the Hampden-Sydney College symposium: Global HIV and AIDS Pandemic: It's In Your Life.  November 5, 2009

Honors/Awards

TOTAL FUNDING = $322,709

2019 - Virginia Academy of Science Mary Louise Andrews Award for Cancer Research for project entitled “The Role of Tumor-associated Chemokine Receptors in Lymph Node Invasion by Melanoma” ($3,000)

2019 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2018 - Virginia Foundation for Independent Colleges Mednick Memorial Fellowship ($2,309)

2018 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2018 - Virginia Mathematics and Science Coalition "Programs That Work" Award (recognizes exemplary mathematics, science, and integrated science, technology, engineering, and mathematics (STEM) programs for which there is evidence of a positive impact on student or teacher learning) for cancer research-based laboratory module to promote undergraduate student learning of gene expression (see 2015 article published in Biochemistry and Molecular Biology Education)

2017 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2016 - Jeffress Trust Awards Program in Interdisciplinary Research Grant for project entitled "Bioinformatic Analysis of CD8+ T Cell Differentiation in Tumor-free Versus Tumor-involved Lymph Nodes ($100,000)

2016 - John Peter Mettauer Award for Excellence in Research (given annually by Hampden-Sydney College to a faculty member to recognize excellence in academic research)

2016 - present - Elliott Endowed Professorship

2016 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2015 - Virginia Association of Science Teachers Recognition in Science Education (RISE) Award - University/College Faculty category (one award given annually among science faculty in Virginia)

2015 - Sigma Xi Chapter Lectureship Subsidy - grant to support visit from Sigma Xi Distinguished Lecturer Dr. Lee Dugatkin (University of Louisville) as a keynote speaker at the 2015 Longwood University/Hampden-Sydney College Sigma Xi Research Sympsoium ($1,200)

2015 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2014 - Commonwealth Health Research Board Grant for project entitled "The Role of Melanoma-derived Factors in Suppressing the Maturation, Activation, and T Cell Stimulatory Capacity of Dendritic Cells" ($125,000)

2014 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2014 - Renewal of Virginia Academy of Science Jeffress Memorial Fellowship ($10,000); Total Grant Award = $45,000

2013 - Virginia Foundation for Independent Colleges Mednick Memorial Fellowship ($2,000)

2013 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2012-2015 - Elliott Endowed Professorship2012 - Renewal of Virginia Academy of Science Jeffress Memorial Fellowship ($10,000)

2012 - Hampden-Sydney College Student/Faculty Summer Research Award ($4,000)

2012 - J. Shelton Horsley Research Award (highest honor bestowed by Virginia Academy of Science for original research) for manuscript published in Cellular Immunology entitled "Suppression of the maturation and activation of the dendritic cell line DC2.4 by melanoma-derived factors."

2011 - Sigma Xi Fresh Faces of the 125th Anniversary Award (1 of 125 members out of 60,000+ worldwide in the international honorary scientific research society recognized as an emerging "Fresh Face" under the age of 35 in scientific research)

2011 - Virginia Academy of Science Jeffress Memorial Fellowship ($25,000)

2011 - Virginia Foundation for Independent Colleges Mednick Memorial Fellowship ($2,000)                        

2011 - Hampden-Sydney Student/Faculty Summer Research Award ($4,000)

2010 - Virginia Foundation for Independent Colleges (VFIC) Undergraduate Science Research Fellowship and Hampden-Sydney Student/Faculty Summer Research Award ($1000)

2010 - Hampden-Sydney Student/Faculty Summer Research Award ($4,000)

Postdoctoral Fellow Immunology Training Grant and Biodefense Training Grant
Who's Who Among American Teachers & Educators
Dean's Fellowship - University of Virginia
Barry M. Goldwater Scholar
Valedictorian - Hampden-Sydney College - 2001
USA Today All-USA College Academic Team - Third Team
Patrick Henry Scholar - Hampden-Sydney College

Student-Mentored Grants/Awards (Total Funds = $46,000)

2019          Corey J. Williams ’19 – Honorable Mention Award in Undergraduate Student Caucus and Poster Competition for poster entitled “The FOXC2 Transcription Factor Promotes Growth of Melanoma Cells in both in vitro and in vivo Settings.”  Presented at 2019 Annual Meeting of the American Association for Cancer Research (Atlanta, GA)  

2019       David Bushhouse ’19 – Samuel S. Jones Phi Beta Kappa Award, awarded annually for top research paper at Hampden-Sydney College ($4,000)

2018          David Bushhouse ’19 – Barry M. Goldwater Scholar (Mathematics, Science, & Engineering) Goldwater Scholarship and Excellence in Education Foundation ($7,500)

2017          Virginia Academy of Science Undergraduate Research Grant to David Bushhouse for project entitled “Identification of FOXC2 Target Genes in Melanoma Through Chromatin Immunoprecipitation” ($750)

2017          Virginia Foundation for Independent Colleges/Carilion Undergraduate Science Research Fellowship to Corey Williams for project entitled “Investigating the Role of Melanoma-associated FOXC2 in Regulating the Expression of Integrins and Other Cell Adhesion Molecules” ($2,000)

2016          James Lau ’17 – Barry M. Goldwater Scholar (Mathematics, Science, & Engineering) Goldwater Scholarship and Excellence in Education Foundation ($7,500)

2016          Sigma Xi Grant-in-Aid of Research to James Lau for project entitled "Investigating the Role of Melanoma-Associated FOXC2 in Tumor Progression " ($1,000)

2015          Virginia Foundation for Independent Colleges Undergraduate Science Research Fellowship to Jefferson Thompson for project entitled "Generation of a Foxc2 Gene Knockout Murine Melanoma Cell Line via CRISPR-Cas9 Genome Editing Technology" ($2,000)

2015          Sigma Xi Grant-in-Aid of Research to Travis Goodloe '16 for project entitled "Validation of a Quantitative Polymerase Chain Reaction (qPCR)-based Method for Detecting Lymph Node Metastasis by Melanoma Cells" ($1,000)

2015       Travis Goodloe ’16 – 1st Place Award in Poster Competition for poster entitled “Validation of a Quantitative Polymerase Chain Reaction (qPCR)-based Method for Detecting Lymph Node Metastasis by Melanoma Cells.”  Presented at Annual Virginia Branch Meeting of the American Society for Microbiology. ($250)

2015       Stephen L. Woodall ’15 – Thematic Best Poster Award for poster entitled “Genetic Engineering of the Murine Melanoma D5.1G4 to Express a Model Antigen for Evaluation of Anti-tumor CD8+ T Cell Responses.”  Presented at Annual Meeting of the American Society of Biochemistry and Molecular Biology (Boston, MA). ($400)

2014          Virginia Foundation for Independent Colleges Undergraduate Science Research Fellowship to Jay Brandt for project entitled "The Effect of Tumor-altered Dendritic Cells on CD8+ T Cells" ($2,000)

2014          Virginia Foundation for Independent Colleges Undergraduate Science Research Fellowship to Drake Bishop for project entitled "Tumor-associated Suppression of the Maturation and Activation of Dendritic Cells" ($2,000)

2014          Samuel S. Jones Phi Beta Kappa Award (awarded annually for top research paper at Hampden-Sydney College) to Drake Bishop for project entitled “Modification of the Maturation and Activation of Murine Dendritic Cells by Wild-type and Gene-silenced Melanomas” ($4,000)

2013          Samuel S. Jones Phi Beta Kappa Award (awarded annually for top research paper at  Hampden-Sydney College) to Yonathan Ararso for project entitled “An shRNA-mediated RNA Silencing Approach to Understand the Role of Melanoma-derived Factors in the Suppression of Dendritic Cell Maturation and Activation” ($4,000)

2013          Sigma Xi Grant-in-Aid of Research to Drake Bishop for project entitled "Melanoma associated Suppression of Dendritic Cell Maturation and Activation" ($500)

2012          Samuel S. Jones Phi Beta Kappa Award (awarded annually for top research paper at Hampden-Sydney College) to Osric Forrest for project entitled “The Effect of B16-F1 and D5.1G4 Tumor-altered Dendritic Cells on Killer T Cell Activation” ($4,000)

2012          Sigma Xi Grant-in-Aid of Research to Yonathan Ararso for project entitled "An shRNA-mediated RNA Silencing Approach to Understand the Role of Melanoma-derived Factors in the Suppression of Dendritic Cell Maturation and Activation" ($1,000)

2011          Sigma Xi Grant-in-Aid of Research to Osric Forrest for project entitled "The Influence of Melanoma Tumor-altered Dendritic Cells on T Cell Activation" ($1,000)

2010    Virginia Foundation for Independent Colleges Undergraduate Science Research Fellowship to Osric Forrest for project entitled "An in vitro Model System for Characterizing the Influence of Tumor Cells and Tumor-derived Factors on Dendritic Cell Phenotype and Function" ($1,000)

2010       Chad Harte ’10 – Best Poster Award for poster entitled “Characterizing Maturation of the Immature Dendritic Cell Line JAWSII.”  Presented at Virginia Collegiate Honors Council Spring Conference. ($100)

Professional Affiliations

Alpha Epsilon Delta - The Health Preprofessional Honor Society (Honorary Member)

European Academy of Tumor Immunology (Invited Member)

American Association for Cancer Research

American Association of Immunologists

Australasian Society for Immunology

Virginia Academy of Sciences (Vice Chair (2011), Secretary (2012), and Chair (2013) of Biology with Microbiology and Molecular Biology Division)

American Association for the Advancement of Science

Sigma Xi Honorary Scientific Research Society (President of Longwood University/Hampden-Sydney College Chapter, 2013-present)

Omicron Delta Kappa Honorary Leadership Fraternity

Phi Beta Kappa Honorary Fraternity

Chi Beta Phi Honorary Science/Mathematics Fraternity

Eta Sigma Phi Honorary Classics Fraternity

Alpha Chi Sigma - Professional Member

Additional Activities

Professinal Development and Service

2019 - Participated in Hampden-Sydney College Experiential Learning Workshop

2015 - Attended the 2015 Virginia Association of Science Teachers (VAST) Professional Development Institute

2015 - Participated in “Basics of detection and analysis—genome editing made easy”                  webinar on CRISPR-Cas9 technology sponsored by Invitrogen

2014 - Participated in "Detection of RNAs with Flow Cytometry" webinar sponsored by                  Affymetrix/eBioscience

2013 - Attended the Sigma Xi Assembly of Delegates Virtual Meeting

2013 - Pre-Med Advisor Workshop at the University of Virginia

2012 - Attended 4-VA Biology Conference at James Madison University (conference to                  discuss strategies for dealing with rising issues and advances in biology instruction);                      served as Discussion Group Facilitator

2011 - Attended 2011 Annual Beirne B. Carter Lecture in Immunology Symposium at University of Virginia

2011 - Participated in shRNA/siRNA webinar sponsored by Qiagen

2011 - Participated in ELISArray webinar sponsored by Qiagen

2010 - Virginia Commonwealth University Pre-Health Advisor Conference at VCU                            Medical Campus

2005-2009 - Piedmont Virginia Community College Laboratory Safety Training (Yearly)

2002 - University of Virginia Animal Handling Training

2002 - The American Association of Immunologists Advanced Course in Immunology at                  Stanford University

2001-2009 - University of Virginia Fire Safety and Prevention Training (Yearly)

2001-2009 - University of Virginia Chemical and Radiation Safety Training (Yearly)

2001-2009 - University of Virginia Bloodborne Pathogens Safety Training (Yearly)

Guest Associate Editor for Research Topic covering Tumor Cell/Dendritic Cell Interactions and the Influence of Tumors on Dendritic Cell-mediated Anti-Tumor Immune Responses and Dendritic Cell-Based Tumor Immunotherapies in the journal Frontiers in Tumor Immunity

Journal/Textbook Review Responsibilities:

American Journal of Immunology

Annual Research & Review in Biology

Cell Biology and Toxicology

Cellular Immunology

Cellular Oncology

Clinical and Translational Medicine

Current Medicinal Chemistry

Frontiers in Immunology

Human Immunology

Immunological Investigations

Immunology

International Immunopharmacology

Journal of Clinical Medicine

Journal of Experimental & Clinical Cancer Research

Melanoma Research

Molecular and Cellular Oncology

Oncotarget

OncoTargets and Therapy

Seminars in Cancer Biology

Kuby, Immunology, 7th Edition textbook

Other Interests  

Juggling
Sports (Basketball, Football, Golf, Tennis)

Research Interests and potential topics for students

The Role of Genetic Factors in the Progression of Melanoma
The Research Fellow will analyze gene expression profiles of highly aggressive versus poorly tumorigenic melanomas in order to gain insight into tumor-promoting gene functions and identify the potential role of genetic factors in regulating cell signaling and biochemical pathways that promote tumor progression.  This work will provide the Fellow with pre-clinical experience in a relevant area of cancer research.